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首页-小分子抑制剂&激动剂-Others-Other Targets-ARN726
ARN726

Chemical Structure : ARN726

CAS No.: 1628343-77-0

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ARN726 (ARN 726, ARN-726)

货号: PC-62874Not For Human Use, Lab Use Only.

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).
ARN726 shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes.
ARN726 exerts profound anti-inflammatory effects in both mouse models and human macrophages.

物理化学性质&存储条件

分子量 268.357
分子式 C14H24N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate

参考文献

1. Ribeiro A, et al. ACS Chem Biol. 2015 Aug 21;10(8):1838-46.

2. Bonezzi FT, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):656-63.

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