ARN3261 (GRN-300) | SIK2/3 inhibitor | Probechem Biochemicals

Chemical Structure : ARN3261

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ARN3261 (GRN-300, ARN-3261)

货号: PC-61952Not For Human Use, Lab Use Only.

ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively.

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生物&药学活性

ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively.
ARN3261 specifically inhibits SIK2-expressed SKOv3 cells with IC50 of 92 nM; demonstrates effectivity against ovarian, breast cancer cell lines alone and in combination with Paclitaxel and Cisplatin.
ARN3261 also inhibits ovarian tumor growth significantly in SKOv3 human ovarian cancer xenografts in mice.

物理化学性质&存储条件

分子量	486.54
分子式	C24H24F2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,5-difluoro-2-methoxyphenyl)-5-(1-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole

参考文献

1. Patent US20140256704 A1.

ARN3261 (GRN-300, ARN-3261)

生物&药学活性

物理化学性质&存储条件

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ARN3261 (GRN-300, ARN-3261)

生物&药学活性

物理化学性质&存储条件

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