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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-ARN24139
ARN24139

Chemical Structure : ARN24139

CAS No.: 2699768-78-8

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ARN24139 (ARN-24139)

货号: PC-28061Not For Human Use, Lab Use Only.

ARN24139 (ARN-24139) is a potent topoisomerase II (Topo II) inhibitor with IC50 of 7.3 uM, shows high cytotoxicity in cancer cell lines (DU145, HeLa, A549) with IC50 of 3.1-4.7 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARN24139 (ARN-24139) is a potent topoisomerase II (Topo II) inhibitor with IC50 of 7.3 uM, shows high cytotoxicity in cancer cell lines (DU145, HeLa, A549) with IC50 of 3.1-4.7 uM.

物理化学性质&存储条件

分子量 499.46
分子式 C24H16F3N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-1,3-diphenyl-2-thioxo-N-[3-(trifluoromethoxy)phenyl]-

参考文献

1. Arencibia JM, et al. J Med Chem. 2020 Apr 9;63(7):3508-3521.

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