ARN24092 | NKCC1 inhibitor | Probechem Biochemicals

Chemical Structure : ARN24092

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ARN24092 (ARN-24092)

货号: PC-72425Not For Human Use, Lab Use Only.

ARN24092 (ARN-4092) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows significant dose-dependent inhibition of NKCC1 in the Ca2+ influx assay (51.9% at 100 uM).

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生物&药学活性

ARN24092 (ARN-4092) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows significant dose-dependent inhibition of NKCC1 in the Ca2+ influx assay (51.9% at 100 uM).
ARN24092 did not show any significant inhibition of NKCC2 in the Cl-influx assay nor inhibition of KCC2 in the thallium (Tl) influx assay.
ARN24092 (i.p, 0.6 mg/kg, daily) restored the short-term working memory of Ts65Dn mice in the T-maze test, completely restored associative memory in Ts65Dn mice in the contextual fear-conditioning (CFC) test, without side effects showed in health of the mice.

物理化学性质&存储条件

分子量	426.451
分子式	C17H25F3N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N,N-dimethylsulfamoyl)-2-hydroxy-5-((8,8,8-trifluorooctyl)amino)benzoic acid

参考文献

1. Borgogno M, et al. J Med Chem. 2021 Jul 22;64(14):10203-10229.

ARN24092 (ARN-24092)

生物&药学活性

物理化学性质&存储条件

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ARN24092 (ARN-24092)

生物&药学活性

物理化学性质&存储条件

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