ARN23765 | 2244458-40-8 | Probechem Biochemicals

Chemical Structure : ARN23765

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ARN23765 (ARN 23765)

货号: PC-38208Not For Human Use, Lab Use Only.

ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.

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生物&药学活性

ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.
ARN23765 is more than 5000-fold lower compared to presently available corrector drugs.
ARN23765 also showed high efficacy, synergy with other types of correctors, and compatibility with chronic VX-770 potentiator.

物理化学性质&存储条件

分子量	615.513
分子式	C30H22F5N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((1-(3-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)(methyl)carbamoyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-7-yl)oxy)benzoic acid

参考文献

1. Nicoletta Pedemonte, et al. Sci Adv. 2020 Feb 21;6(8):eaay9669.

ARN23765 (ARN 23765)

生物&药学活性

物理化学性质&存储条件

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ARN23765 (ARN 23765)

生物&药学活性

物理化学性质&存储条件

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