ARN19689 | NAAA inhibitor | Probechem Biochemicals

Chemical Structure : ARN19689

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ARN19689 (ARN-19689)

货号: PC-72102Not For Human Use, Lab Use Only.

ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA).

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ARN19702 (ARN-19702) is potent, selective, non-covalent inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 42 nM (h-NAAA). ARN19702 showed a very high selectivity toward both human FAAH and human acid ceramidase (AC), both IC50>30 uM.
ARN1970 binds to human NAAA in a non-covalent manner.
ARN1970 shows a good efficacy and biochemical profile, and preliminary in vitro ADME properties.
ARN1970 represents a valuable tool to be further investigated in animal models of inflammatory conditions.

物理化学性质&存储条件

分子量	421.516
分子式	C19H27N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3r,5S)-8-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)-3-((5-(ethoxymethyl)pyrazin-2-yl)oxy)-8-azabicyclo[3.2.1]octane

参考文献

1. Paolo Di Fruscia, et al. J Med Chem. 2021 Sep 23;64(18):13327-13355.

ARN19689 (ARN-19689)

生物&药学活性

物理化学性质&存储条件

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ARN19689 (ARN-19689)

生物&药学活性

物理化学性质&存储条件

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