ARN16186 | NAAA inhibitor | Probechem Biochemicals

Chemical Structure : ARN16186

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ARN16186 (ARN-16186)

货号: PC-22336Not For Human Use, Lab Use Only.

ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.

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生物&药学活性

ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.
ARN16186 displays little to no activity against human acid ceramidase (h-AC) and fatty acid amide hydrolase (h-FAAH) at 10 uM.
ARN16186 inhibits NAAA in a noncovalent manner.
ARN16186 increases PEA and OEA levels and reduces NF-kB and STAT3 DNA-binding activity in the spinal cord of mice.
ARN16186 reduces mononuclear cell infiltrate in the spinal cord and affects the CD4+T lymphocyte population, reduces the progression and severity of symptoms in EAE mice model.

物理化学性质&存储条件

分子量	417.57
分子式	C22H31N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3r,5S)-3-(4-butylphenoxy)-8-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-8-azabicyclo[3.2.1]octane

参考文献

1. Sgroi S, et al. Pharmacol Res. 2021 Oct;172:105816.

ARN16186 (ARN-16186)

生物&药学活性

物理化学性质&存储条件

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ARN16186 (ARN-16186)

生物&药学活性

物理化学性质&存储条件

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