ARN14494 | Serine palmitoyltransferase inhibitor | Probechem Biochemicals

Chemical Structure : ARN14494

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ARN14494 (ARN-14494, ARN 14494)

货号: PC-35857Not For Human Use, Lab Use Only.

ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM.

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生物&药学活性

ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM.
ARN14494 prevents the synthesis of pro-inflammatory cytokines TNFα and IL1β, growth factor TGFβ1, and oxidative stress-related enzymes iNOS and COX2 in mouse primary cortical astrocytes.
ARN14494 also exerts neuroprotective properties in primary cortical neurons.
ARN14494 inhibits the synthesis of long-chain ceramides and dihydroceramides that are involved in AD progression, promotes neuronal survival after astrocyte amyloid beta 1-42 injury.

物理化学性质&存储条件

分子量	424.545
分子式	C24H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl)piperidin-4-yl)-N-methyl-2-oxoindoline-5-carboxamide

参考文献

1. De Vita T, et al. ACS Chem Neurosci. 2018 Nov 27. doi: 10.1021/acschemneuro.8b00556.

ARN14494 (ARN-14494, ARN 14494)

生物&药学活性

物理化学性质&存储条件

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ARN14494 (ARN-14494, ARN 14494)

生物&药学活性

物理化学性质&存储条件

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