ARN077 |CAS:1373625-34-3 Probechem Biochemicals

Chemical Structure : ARN077

CAS No.: 1373625-34-3

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ARN077 (ARN-077)

货号: PC-62873Not For Human Use, Lab Use Only.

ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4380	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.
ARN077 attenuates heat hyperalgesia and mechanical allodynia elicited in mice by carrageenan injection or sciatic nerve ligation in a dose-dependent manner, reverses the allodynia caused by ultraviolet B radiation in rats.
ARN077 also suppresses DNFB-induced inflammation pruritus in mouse model of allergic dermatitis.

物理化学性质&存储条件

分子量	291.347
分子式	C16H21NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Phenylpentyl ((2S,3R)-2-methyl-4-oxooxetan-3-yl)carbamate

参考文献

1. Ponzano S, et al. J Med Chem. 2013 Sep 12;56(17):6917-34.

2. Sasso O, et al. Pain. 2013 Mar;154(3):350-60.

3. Romeo E, et al. ACS Chem Biol. 2015 Sep 18;10(9):2057-64.

4. Sasso O, et al. J Invest Dermatol. 2018 Mar;138(3):562-569.

ARN077 (ARN-077)

生物&药学活性

物理化学性质&存储条件

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ARN077 (ARN-077)

生物&药学活性

物理化学性质&存储条件

参考文献

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