ARN-75039 | Arenavirus inhibitor | Probechem Biochemicals

Chemical Structure : ARN-75039

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ARN-75039 (ARN75039)

货号: PC-72615Not For Human Use, Lab Use Only.

ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.

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生物&药学活性

ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.
ARN-75039 demonstrated sub-nanomolar EC50 activity against pTCRV that further translated to native wild-and NWAs, including LASV, JUNV and MACV, in pseudotyped virus assays and against native replicative LASV and JUNV.
ARN-75039 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.
ARN-75039 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.

物理化学性质&存储条件

分子量	414.549
分子式	C27H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(tert-butoxy)phenyl)-6-(4-isopropoxyphenyl)-7-methylimidazo[1,2-a]pyridine

参考文献

1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125.

2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983.

ARN-75039 (ARN75039)

生物&药学活性

物理化学性质&存储条件

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ARN-75039 (ARN75039)

生物&药学活性

物理化学性质&存储条件

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