ARN-5187 |CAS:1287451-26-6 Probechem Biochemicals

Chemical Structure : ARN-5187

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ARN-5187 (ARN5187;ARN 5187)

货号: PC-61357Not For Human Use, Lab Use Only.

ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.

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1 g		Get quote

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生物&药学活性

ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.
ARN-5187 relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells.
ARN-5187 disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability.
ARN-5187 a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine.

物理化学性质&存储条件

分子量	397.538
分子式	C24H32FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[[1-(2-Fluorophenyl)cyclopentyl]amino]methyl]-2-[(4-methyl-1-piperazinyl)methyl]phenol

参考文献

1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608.

ARN-5187 (ARN5187;ARN 5187)

生物&药学活性

物理化学性质&存储条件

参考文献

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ARN-5187 (ARN5187;ARN 5187)

生物&药学活性

物理化学性质&存储条件

参考文献

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