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首页-小分子抑制剂&激动剂-Others-Other Targets-ARC39
ARC39

Chemical Structure : ARC39

CAS No.: 15049-93-1

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ARC39

货号: PC-23808Not For Human Use, Lab Use Only.

ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IO50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IO50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro.
ARC39 dose- and time-dependently inhibits lysosomal ASM in intact cells.
ARC39 inhibits platelet- and ASM-promoted adhesion of tumor cells.

物理化学性质&存储条件

分子量 317.26
分子式 C10H25NO6P2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-aminodecylidene bis-phosphonic acid

参考文献

1. McVey MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L625-L637.

2. Naser E, et al. J Lipid Res. 2020 Jun;61(6):896-910.

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