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首页-小分子抑制剂&激动剂-Immunology/Inflammation-PD-1/PD-L1-ARB-272572
ARB-272572

Chemical Structure : ARB-272572

CAS No.: 2368182-63-0

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ARB-272572 (ARB272572, Compound A)

货号: PC-72493Not For Human Use, Lab Use Only.

ARB-272572 (ARB272572, Compound A) is a potent small-molecule PD-L1 inhibitor, inhibits PD-1/PD-L1 with HTRF IC50 of 0.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ARB-272572 (ARB272572, Compound A) is a potent small-molecule PD-L1 inhibitor, inhibits PD-1/PD-L1 with HTRF IC50 of 0.4 nM.
ARB-272572 induces PD-L1 dimerization and internalization, exhibits similar upregulation of CMV responses as αPD-L1 antibodies in CMV recall assay with IC50 of 3.0 nM.
ARB-272572 is a potent in vitro inhibitor of PD-1/PD-L1 cell signaling through induction of PD-L1 protein homo-interactions, which can lead to immunostimulatory activity in human primary cells.
ARB-272572 inhibits tumor growth of PD-1/PD-L1 humanized mice implanted with MC38 cells expressing humanized PD-L1 (10 mg/kg orally).
ARB-272572 enhance HBV-specific immune responses not only activated Ag-specific T cells (IFN-γ production), but also directly stimulated Ag-specific B cells to proliferate and differentiate into Ab-secreting cells.

物理化学性质&存储条件

分子量 568.678
分子式 C32H36N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-(2,2'-Dimethyl[1,1'-biphenyl]-3,3'-diyl)bis(5-{[(2-hydroxyethyl)amino]methyl}pyridine-2-carboxamide)

参考文献

1. Jang-June Park, et al. Nat Commun. 2021 Feb 22;12(1):1222.

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