AR420626 | GPR41 agonist | Probechem Biochemicals

Chemical Structure : AR420626

CAS No.: 1798310-55-0

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AR420626 (AR 420626)

货号: PC-49032Not For Human Use, Lab Use Only.

AR420626 is a potent, selective GPR41/FFA3 agonist with pEC50 of 5.74 in [35S]GTPγS-binding assays, induces apoptosis in HCC cells, including HepG2 and HLE cells.

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10 mg	￥1580	In stock
25 mg	￥2780	In stock
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生物&药学活性

AR420626 is a potent, selective GPR41/FFA3 agonist with pEC50 of 5.74 in [35S]GTPγS-binding assays, induces apoptosis in HCC cells, including HepG2 and HLE cells.
AR420626 elicits an extrinsic apoptotic pathway and histone deacetylase inhibition, and inhibits growth of HepG2 xenografts.
AR420626 induces apoptosis via the TNF-α-induced extrinsic apoptotic pathway.AR420626 induces apoptosis via activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway in HepG2 cells.

物理化学性质&存储条件

分子量	417.286
分子式	C21H18Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxamide

参考文献

1. Mikami D, et al. Ther Adv Med Oncol. 2020 Mar 20;12:1758835920913432.

2. Said H, et al. Dig Dis Sci. 2017 Aug;62(8):1944-1952.

3. Brian D Hudson, et al. Mol Pharmacol. 2014 Aug;86(2):200-10.

AR420626 (AR 420626)

生物&药学活性

物理化学性质&存储条件

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AR420626 (AR 420626)

生物&药学活性

物理化学性质&存储条件

参考文献

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