AR-R17779 hydrochloride | α7nAChR agonist | Probechem Biochemicals

Chemical Structure : AR-R17779 hydrochloride

CAS No.: 178419-42-6

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AR-R17779 hydrochloride (AR-R 17779)

货号: PC-25934Not For Human Use, Lab Use Only.

AR-R17779 hydrochloride is a potent, selective and full alpha7 nicotinic acetylcholine receptor (α7nAChR) agonist with Ki of 92 nM, >150-fold selective over α4β2 subtype.

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10 mg	￥2980	In stock
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生物&药学活性

AR-R17779 hydrochloride is a potent, selective and full alpha7 nicotinic acetylcholine receptor (α7nAChR) agonist with Ki of 92 nM, >150-fold selective over α4β2 subtype.
AR-R17779 hydrochloride improves learning in two radial-arm maze tasks and reversed working memory impairment caused by fimbria-fornix sections.
AR-R17779 hydrochloride also has anxiolytic activity.
AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.

物理化学性质&存储条件

分子量	218.68
分子式	C9H15ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1'-Azaspiro[oxazolidine-5,3'-bicyclo[2.2.2]octan]-2-one hydrochloride

参考文献

1. E D Levin, et al. Behav Pharmacol. 1999 Nov;10(6-7):675-80.

2. Van Kampen M, et al. Psychopharmacology (Berl). 2004 Apr;172(4):375-83.

3. Mullen G, et al. J Med Chem. 2000 Nov 2;43(22):4045-50.

AR-R17779 hydrochloride (AR-R 17779)

生物&药学活性

物理化学性质&存储条件

参考文献

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AR-R17779 hydrochloride (AR-R 17779)

生物&药学活性

物理化学性质&存储条件

参考文献

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