AR-A014418 |CAS:487021-52-3 Probechem Biochemicals

Chemical Structure : AR-A014418

CAS No.: 487021-52-3

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AR-A014418 (AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor)

货号: PC-42628Not For Human Use, Lab Use Only.

AR-A014418 is a potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.

规格	价格	库存
25 mg	￥1980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AR-A014418 is a potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.
AR-A014418 shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases.
AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.

物理化学性质&存储条件

分子量	308.3131
分子式	C12H12N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-

参考文献

1. Bhat R, et al. J Biol Chem. 2003 Nov 14;278(46):45937-45.

2. Martins DF, et al. J Pain. 2011 Mar;12(3):315-22.

3. Mazzardo-Martins L, et al. Neuroscience. 2012 Dec 13;226:411-20.

AR-A014418 (AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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AR-A014418 (AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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