AR-001 | Adenosine A1 receptor agonist | Probechem Biochemicals

Chemical Structure : AR-001

加入收藏

AR-001 (AR001)

货号: PC-22838Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AR-001 is a selective adenosine A1 receptor agonist with EC50 of 9.35 uM in HEK293-aeqα15/ADORA1 cells, increases adenosine A1 receptor expression and mRNA level in the hypothalamus of mice, exhibits hypnotic efficacy.
AR-001 significantly affects the onset latency to sleep and total sleep time in mice.
AR-001 decreases the neuronal activity in wake-promoting brain regions and increase the neuronal activity in hypnotic brain regions, which is significantly reversed by the highly-selective adenosine A1 receptor antagonist DPCPX.
AR-001 treatment induced mRNA expression of adenosine A1 receptor and activation of NF-κB in hypothalamus of the mouse brain.

物理化学性质&存储条件

分子量	268.32
分子式	C15H16N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-ethyl-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

参考文献

1. Kim S, et al. Eur J Pharmacol. 2024 Jul 30:176847.

AR-001 (AR001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AR-001 (AR001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.