AQX-MN100 | SHIP1 agonist | Probechem Biochemicals

Chemical Structure : AQX-MN100

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AQX-MN100 (ZPR-MN100)

货号: PC-20548Not For Human Use, Lab Use Only.

AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.

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生物&药学活性

AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro.
AQX-MN100 selectively inhibited TNFα production from SHIP1+/+ but not SHIP1−/− macrophages with EC50 of 0.3-0.6 uM.
AQX-MN100 efficiently inhibited the LPS-induced elevation of plasma TNFα levels in the mouse endotoxemia model.
AQX-MN100 dramatically inhibited DNFB-induced neutrophil-specific myeloperoxidase (MPO) in sensitized mice, also inhibited DNFB-induced inflammation.

物理化学性质&存储条件

分子量	312.50
分子式	C22H32O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1=CC2=C(C(C)=C1)[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2

参考文献

1. Christopher J Ong, et al. Blood. 2007 Sep 15;110(6):1942-9.

AQX-MN100 (ZPR-MN100)

生物&药学活性

物理化学性质&存储条件

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AQX-MN100 (ZPR-MN100)

生物&药学活性

物理化学性质&存储条件

参考文献

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