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首页-小分子抑制剂&激动剂-Others-Other Targets-AQX-435
AQX-435

Chemical Structure : AQX-435

CAS No.: 1619983-52-6

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AQX-435 (AQX435, AQX-C5)

货号: PC-72440Not For Human Use, Lab Use Only.

AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
    AQX-435 co-operated with the BTK inhibitor ibrutinib to enhance inhibition of anti-IgM-induced AKT phosphorylation.
    AQX-435 induced caspase-dependent apoptosis of CLL cells preferentially as compared to normal B cells.
    AQX-435 induced TMD8 cell apoptosis in vitro with an IC50 of 2 uM, and overcame in vitro survival promoting effects of microenvironmental stimuli.
    AQX-435 reduced AKT phosphorylation and growth of DLBCL in vivo, and co-operated with ibrutinib for tumor growth inhibition.

    物理化学性质&存储条件

    分子量 450.579
    分子式 C27H34N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2R,3S,4S,4aS,8aS)-4-(3,5-dihydroxybenzoyl)-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl)nicotinamide

    参考文献

    1. Elizabeth A Lemm, et al. Clin Cancer Res. 2020 Apr 1;26(7):1700-1711.

    2. Packham G, et al. Cancer Research. 2018;78(13).

    3. Packham G, et al. Blood. 2016;128(22):2037.

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