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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-AQX-016A
AQX-016A

Chemical Structure : AQX-016A

CAS No.: 849669-54-1

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AQX-016A (AQX016A, NSC 741764)

货号: PC-38538Not For Human Use, Lab Use Only.

AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity.
AQX-016A decreased PI(3,4,5)P3 levels in LPS treated macrophages, but not PI3K inhibitor LY294002.
AQX-016A reduced TNFα in LPS challenged bone marrow-derived macrophages (BMDM).

物理化学性质&存储条件

分子量 328.496
分子式 C22H32O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6aR,11aR,11bS)-4,4,6a,7,11b-pentamethyl-1,2,3,4a,5,6,11,11a-octahydrobenzo[a]fluorene-9,10-diol

参考文献

1. Ong CJ, et al. Blood. 2007 Sep 15;110(6):1942-9.

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