AQW-051 |CAS:669770-29-0 Probechem Biochemicals

Chemical Structure : AQW-051

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AQW-051 (AQW051;AQW 051)

货号: PC-61600Not For Human Use, Lab Use Only.

AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56.

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生物&药学活性

AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56; displays high selectivity (>100-fold) over other nACh receptors; stimulates calcium influx in GH3–ha7-22 cells recombinantly expressing the human α7-nACh receptor with pEC50 of 7.41; facilitates learning/memory performance in mice; reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys.

Parkinson Disease

Phase 2 Clinical

物理化学性质&存储条件

分子量	294.398
分子式	C19H22N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-3-{[6-(4-methylphenyl)pyridin-3-yl]oxy}-1-azabicyclo[2.2.2]octane

参考文献

1. Feuerbach D, et al. Br J Pharmacol. 2015 Mar;172(5):1292-304.

2. Di Paolo T, et al. Parkinsonism Relat Disord. 2014 Nov;20(11):1119-23.

3. Beinat C, et al. CNS Drugs. 2015 Jul;29(7):529-42.

4. Trenkwalder C, et al. Mov Disord. 2016 Jul;31(7):1049-54.

AQW-051 (AQW051;AQW 051)

生物&药学活性

物理化学性质&存储条件

参考文献

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AQW-051 (AQW051;AQW 051)

生物&药学活性

物理化学性质&存储条件

参考文献

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