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首页-小分子抑制剂&激动剂-Others-Other Targets-AQIM-I
AQIM-I

Chemical Structure : AQIM-I

CAS No.: 2247881-73-6

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AQIM-I

货号: PC-21551Not For Human Use, Lab Use Only.

AQIM-I is a highly potent small molecule survivin inhibitor by targeting ILF3/NF110, binds to ILF3/NF110 with KD value of 163 nM in SPR assays, has broad-spectrum antitumor activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AQIM-I is a highly potent small molecule survivin inhibitor by targeting ILF3/NF110, binds to ILF3/NF110 with KD value of 163 nM in SPR assays, has broad-spectrum antitumor activity.
    AQIM-I exhibits high antiproliferation potency and excellent selectivity with IC50 values of 0.009 and 21.5 μM against A549 and L929, respectively.
    AQIM-I exhibits potent activity against MCF-7 and TE-1, with IC50 values of 0.06 and 0.05 μM, respectively, and considerable potency against H460 (IC50 = 0.14 μM), 5637 (IC50 = 0.18 μM), HepG2 (IC50 = 0.25 μM), H1299 (IC50 = 0.51 μM), and 143B (IC50 = 0.59 μM).
    AQIM-I predominantly shows significant antiproliferative activity against cancer cells and low toxicity against normal cells.
    AQIM-I produces ROS and causes DNA damage in A549 cells, induces the cell cycle G0/G1 phase arrest, induces apoptosis and autophagy of A549 cells.
    AQIM-I attenuates the enhanced survivin promoter activity induced by the overexpression of ILF3/NF110.
    AQIM-I (2 mg/kg) markedly inhibits tumor growth in vivo and exhibits greater safety than YM155 and DOX.

    物理化学性质&存储条件

    分子量 404.21
    分子式 C17H13IN2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,3-dimethyl-4,11-dioxo-4,11-dihydro-1H-anthra[2,3-d]imidazol-3-ium iodide

    参考文献

    1. Yuan J, et al. J Med Chem. 2023 Dec 11. doi: 10.1021/acs.jmedchem.3c01551.

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