AQIM-I

Chemical Structure : AQIM-I

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货号: PC-21551Not For Human Use, Lab Use Only.

AQIM-I is a highly potent small molecule survivin inhibitor by targeting ILF3/NF110, binds to ILF3/NF110 with KD value of 163 nM in SPR assays, has broad-spectrum antitumor activity.

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生物&药学活性

AQIM-I is a highly potent small molecule survivin inhibitor by targeting ILF3/NF110, binds to ILF3/NF110 with KD value of 163 nM in SPR assays, has broad-spectrum antitumor activity.
AQIM-I exhibits high antiproliferation potency and excellent selectivity with IC50 values of 0.009 and 21.5 μM against A549 and L929, respectively.
AQIM-I exhibits potent activity against MCF-7 and TE-1, with IC50 values of 0.06 and 0.05 μM, respectively, and considerable potency against H460 (IC50 = 0.14 μM), 5637 (IC50 = 0.18 μM), HepG2 (IC50 = 0.25 μM), H1299 (IC50 = 0.51 μM), and 143B (IC50 = 0.59 μM).
AQIM-I predominantly shows significant antiproliferative activity against cancer cells and low toxicity against normal cells.
AQIM-I produces ROS and causes DNA damage in A549 cells, induces the cell cycle G0/G1 phase arrest, induces apoptosis and autophagy of A549 cells.
AQIM-I attenuates the enhanced survivin promoter activity induced by the overexpression of ILF3/NF110.
AQIM-I (2 mg/kg) markedly inhibits tumor growth in vivo and exhibits greater safety than YM155 and DOX.

物理化学性质&存储条件

分子量	404.21
分子式	C17H13IN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-dimethyl-4,11-dioxo-4,11-dihydro-1H-anthra[2,3-d]imidazol-3-ium iodide

参考文献

1. Yuan J, et al. J Med Chem. 2023 Dec 11. doi: 10.1021/acs.jmedchem.3c01551.

AQIM-I

生物&药学活性

物理化学性质&存储条件

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AQIM-I

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物理化学性质&存储条件

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