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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-APY29
APY29

Chemical Structure : APY29

CAS No.: 1216665-49-4

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APY29 (IRE1α inhibitor APY29, APY-29)

货号: PC-45337Not For Human Use, Lab Use Only.

APY-29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.

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5 mg ￥580 In stock
10 mg ￥880 In stock
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50 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

APY29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.
APY29 divergently affects IRE1α oligomerization, demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.

物理化学性质&存储条件

分子量 332.3625
分子式 C17H16N8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mg/mL
Chemical Name/SMILES

2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-

参考文献

1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.

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