APX2009 | Ref-1/APE1 inhibitor | Probechem Biochemicals

Chemical Structure : APX2009

CAS No.: 1415030-15-7

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APX2009 (APX 2009, APX-2009)

货号: PC-60633Not For Human Use, Lab Use Only.

APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition.
APX2009 inhibits endothelial cell proliferation in HRECs and Rf/6a cells in vitro with GI50 of 1.1 and 26 uM, respectively.
APX2009 significantly inhibits endothelial tube formation in HRECs and Rf/6a cells in vitro, inhibits TNF-α mediated NF-κB signaling and proangiogenic target gene mRNA expression.
APX2009 inhibits choroidal sprouting at low micromolar in ex vivo, blocks ocular angiogenesis in vitro and ex vivo.

物理化学性质&存储条件

分子量	355.43
分子式	C21H25NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide

参考文献

1. Kelley MR, et al. J Pharmacol Exp Ther. 2016 Nov;359(2):300-309.

APX2009 (APX 2009, APX-2009)

生物&药学活性

物理化学性质&存储条件

参考文献

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APX2009 (APX 2009, APX-2009)

生物&药学活性

物理化学性质&存储条件

参考文献

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