APX-115 freebase |CAS:1270084-92-8 Probechem Biochemicals

Chemical Structure : APX-115 freebase

CAS No.: 1270084-92-8

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APX-115 freebase (Isuzinaxib;Ewha 18278;APX 115;APX115)

货号: PC-60409Not For Human Use, Lab Use Only.

Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

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10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
APX-115 shows no inhibitory activities on xanthine oxidase and glucose oxidase.
APX-115 inhibits the responses of BMMs to RANKL, including ROS generation, activation of MAPK and NF-κB, and osteoclast cells differentiation.
APX-115 protects db/db mice from renal injury.

物理化学性质&存储条件

分子量	279.343
分子式	C17H17N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol

参考文献

1. Cha JJ, et al. Lab Invest. 2017 Apr;97(4):419-431.

2. Kwon G, et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18540.

3. Joo JH, et al. Sci Rep. 2016 Mar 15;6:22389.

APX-115 freebase (Isuzinaxib;Ewha 18278;APX 115;APX115)

生物&药学活性

物理化学性质&存储条件

参考文献

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APX-115 freebase (Isuzinaxib;Ewha 18278;APX 115;APX115)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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