APTO-253 hydrochloride |CAS:1422731-37-0 Probechem Biochemicals

Chemical Structure : APTO-253 hydrochloride

加入收藏

APTO-253 hydrochloride (APTO253;LOR253;LOR-253)

货号: PC-35076Not For Human Use, Lab Use Only.

APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.

规格	价格	库存	数量
10 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

APTO-253 (LOR-253) hydrochloride is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3].
APTO-253 selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.

物理化学性质&存储条件

分子量	403.845
分子式	C22H15ClFN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline hydrochloride

参考文献

1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834.

2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92.

3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.

4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.

APTO-253 hydrochloride (APTO253;LOR253;LOR-253)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

APTO-253 hydrochloride (APTO253;LOR253;LOR-253)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.