APP degrader 0152 (APP degrader-1)

Chemical Structure : APP degrader 0152

CAS No.: 3090769-17-5

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货号: PC-28069Not For Human Use, Lab Use Only.

APP degrader 0152 (Compound 0152) is a potent, CAPRIN1-dependent molecule glue degrader of amyloid precursor protein (APP), effectively reduces intracellular APP and extracellular Aβ42 without neuronal toxicity, effectively lowers Aβ42 secretion with IC50 of 0.9 uM in AG27606 neurons.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

APP degrader 0152 (Compound 0152) is a potent, CAPRIN1-dependent molecule glue degrader of amyloid precursor protein (APP), effectively reduces intracellular APP and extracellular Aβ42 without neuronal toxicity, effectively lowers Aβ42 secretion with IC50 of 0.9 uM in AG27606 neurons.
Compound 0152 stabilizes the CAPRIN1‐APP interaction, consistent with a molecular glue mechanism.
Compound 0152 directs APP to lysosomes via CAPRIN1, induces lysosomal degradation of APP in AD iPSC-Ns.
Compound 0152 significantly reduces APP/Aβ42 accumulation in AD iPSC‐derived organoids.
Compound 0152 (100 mg/kg, IP) reduces amyloid burden in 5xFAD mice.

物理化学性质&存储条件

分子量	412.46
分子式	C20H20N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-methoxyphenyl)-3-(6-(morpholine-4-carbonyl)benzo[d]thiazol-2-yl)urea

参考文献

1. Jung S, et al. Adv Sci (Weinh). 2026 Sep 1:e77575.