APOD53 | TRF2 inhibitor | Probechem Biochemicals

Chemical Structure : APOD53

加入收藏

APOD53 (TRF2 inhibitor)

货号: PC-21932Not For Human Use, Lab Use Only.

APOD53 is a specific, covalent cyclic peptide binder / inhibitor of TRF2 TRFH domain, prevents recruitment of RTEL1 and SLX4 to TRF2 in cells, impairs cancer cell growth.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

APOD53 is a specific, covalent cyclic peptide binder / inhibitor of TRF2 TRFH domain, prevents recruitment of RTEL1 and SLX4 to TRF2 in cells, impairs cancer cell growth.
APOD53 specfically binds to TRF2 Cys160.
APOD53 induces telomeric dysfunction and alter ALT-associated phenotypes, also increases the total intensity of phosphorylated H2AX (γH2AX) in both HeLa and U-2 OS cells, indicative of a wider DDR.
APOD53 does not induce NHEJ-associated telomere fusions.
Co-treatment with APOD53 and G4 stabilizer RHPS4 results in enhanced replication stress at the telomere.

物理化学性质&存储条件

分子量	826.95
分子式	C40H58N8O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,12R,15S,22R,23aS)-12-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-22-acryloyl-18-((R)-1-hydroxyethyl)-15-isobutyl-1,9,13,16,19-pentaoxodocosahydro-1H-pyrrolo[2,1-c][1,4,7,10,16]pentaazacyclohenicosine-3-carboxamide

参考文献

1. Sobinoff AP, et al. Cell Chem Biol. 2023 Dec 21;30(12):1652-1665.e6.