APL-11056 (APL11056)

Chemical Structure : APL-11056

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货号: PC-28567Not For Human Use, Lab Use Only.

APL-11056 is a potent and selective inhibitor of PKR-like endoplasmic reticulum kinase (PERK, EIF2AK3) with cell IC50 of 18 nM.

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APL-11056 is a potent and selective inhibitor of PKR-like endoplasmic reticulum kinase (PERK, EIF2AK3) with cell IC50 of 18 nM.

分子量	446.37
分子式	C20H14F4N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(4-(7-Amino-3-methyl-1H-pyrazolo[4,3-d]pyrimidin-1-yl)-2,3-difluorophenyl)-2-(3,5-difluorophenyl)-2-hydroxyacetamide

1. Glossop PA, et al. J Med Chem. 2026 Oct 22;69(20):24619-24644.