APA modulator T5 |CAS:1293394-50-9 Probechem Biochemicals

Chemical Structure : APA modulator T5

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APA modulator T5 (Alternative polyadenylation modulator)

货号: PC-35767Not For Human Use, Lab Use Only.

APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.
APA modulator T5 predominantly induced CR-APA and UTR-APA.
APA modulator T5 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway.
APA modulator T5 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing.

物理化学性质&存储条件

分子量	329.403
分子式	C21H19N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclobutyl-6-(2-naphthylmethyl)-2,7-dihydro4H-pyrazolo[3,4-b]pyridin-4-one

参考文献

1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5.

APA modulator T5 (Alternative polyadenylation modulator)

生物&药学活性

物理化学性质&存储条件

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APA modulator T5 (Alternative polyadenylation modulator)

生物&药学活性

物理化学性质&存储条件

参考文献

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