APA modulator T4 |CAS:785708-33-0 Probechem Biochemicals

Chemical Structure : APA modulator T4

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APA modulator T4 (Alternative polyadenylation modulator)

货号: PC-35766Not For Human Use, Lab Use Only.

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.

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生物&药学活性

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.
APA modulator T4 does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA.
APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway.
APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing.

物理化学性质&存储条件

分子量	377.444
分子式	C22H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl) quinazoline4(3H)-one

参考文献

1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5.

APA modulator T4 (Alternative polyadenylation modulator)

生物&药学活性

物理化学性质&存储条件

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APA modulator T4 (Alternative polyadenylation modulator)

生物&药学活性

物理化学性质&存储条件

参考文献

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