AP736 | | Probechem Biochemicals

Chemical Structure : AP736

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AP736 (AP 736)

货号: PC-21492Not For Human Use, Lab Use Only.

AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.

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生物&药学活性

AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.
AP736 inhibits key melanogenic enzymes and the suppression of PKA-CREB signaling pathway.
AP736 markedly inhibits intracellular tyrosinase activity in the α-MSH-stimulated B16F10 melanoma cells.
AP736 does not directly inhibit tyrosinase activity.
AP736 induces GSK3β phosphorylation and reduces the MITF protein level.

物理化学性质&存储条件

分子量	437.54
分子式	C26H31NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(adamantan-1-yl)-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide

参考文献

1. Lee CS, et al. Exp Dermatol. 2013 Nov;22(11):762-4.

2. Shin HJ, et al. Int J Mol Med. 2015 Nov;36(5):1353-60.

AP736 (AP 736)

生物&药学活性

物理化学性质&存储条件

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AP736 (AP 736)

生物&药学活性

物理化学性质&存储条件

参考文献

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