AP20187 | FKBP ligand | Probechem Biochemicals

Chemical Structure : AP20187

CAS No.: 195514-80-8

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AP20187 (AP-20187, AP 20187)

货号: PC-35968Not For Human Use, Lab Use Only.

AP20187 (AP-20187, AP 20187) is a cell-permeable, semisynthetic bivalent ligand (dimerizer) of FK506-binding protein (FKBP F36V).

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

AP20187 (AP-20187, AP 20187) is a cell-permeable, semisynthetic bivalent ligand (dimerizer) of FK506-binding protein (FKBP F36V).
AP20187 potently inhibits the differentiation of transfected myoblasts in the absence of bFGF, blocks myotube formation and myosin heavy chain expression and stimulates MAP kinase phosphorylation in transfected cells.
AP20187 dramatically suppressed LNCaP tumor growth in nude mice and led to a significantly increased host survival.

物理化学性质&存储条件

分子量	1482.773
分子式	C82H107N5O20
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)

参考文献

1. Whitney ML, et al. J Biol Chem. 2001 Nov 2;276(44):41191-6.

2. Xie X, et al. Cancer Res. 2001 Sep 15;61(18):6795-804.

3. Feng H, et al. Blood. 2001 Jun 1;97(11):3505-12.

4. Richard RE, et al. Mol Ther. 2004 Oct;10(4):730-40.

AP20187 (AP-20187, AP 20187)

生物&药学活性

物理化学性质&存储条件

参考文献

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AP20187 (AP-20187, AP 20187)

生物&药学活性

物理化学性质&存储条件

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