AP-18 | TRPA1 inhibitor | Probechem Biochemicals

Chemical Structure : AP-18

CAS No.: 55224-94-7

加入收藏

AP-18 (TRPA1 inhibitor)

货号: PC-24809Not For Human Use, Lab Use Only.

AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively.
AP-18 shows no effect on TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8.
AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide in CHO cells assayed by ratiometric Ca2+ imaging.
AP-18 blocks cold- and mustard-oil-induced activation of mouse TRPA1.
AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes.
AP-18 reverses complete CFA-induced mechanical hyperalgesia in mice.

物理化学性质&存储条件

分子量	209.67
分子式	C11H12ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime

参考文献

1. Petrus M, et al. Mol Pain. 2007;3:40. Published 2007 Dec 17.

AP-18 (TRPA1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AP-18 (TRPA1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.