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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -AOH1996
AOH1996

Chemical Structure : AOH1996

CAS No.: 2089314-64-5

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AOH1996 (AOH 1996, AOH-1996)

货号: PC-20997Not For Human Use, Lab Use Only.

AOH1996 (AOH-1996) is a small molecule, orally active inhibitor of cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), exerts potent, selective anticancer effects.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2880 In stock
25 mg ￥4580 In stock
50 mg ￥7580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AOH1996 (AOH-1996) is a small molecule, orally active inhibitor of cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), exerts potent, selective anticancer effects.
AOH1996 targets the PIP box and APIM binding domain of PCNA, and stabilizes the interaction between PCNA and RPB1, thereby interfering with the resolution of transcription-replication conflicts.
AOH1996 is an analog of AOH1160 (Cat. PC-35301) that exhibits remarkable therapeutic properties.
AOH1996 stabilizes the interaction between chromatin-bound PCNA and the largest subunit (RBP1) of RNA polymerase II (RNAPII), leading to degradation of the intracellular RPB1.
AOH1996 also dissociates PCNA from actively transcribed chromatin and causes DSB accumulation, without affecting the presence of PCNA in the heterochromatin region.
AOH1996 induces a substantial change in cell-cycle profile that indicates G2/M and/or S phase arrest in cancer cells, but not non-malignant stem cells.
AOH1996 significantly reduced the tumor burden in mice bearing xenograft tumors derived from either neuroblastoma, breast cancer, or small cell lung cancer cells, with no discernable side effects.

物理化学性质&存储条件

分子量 426.47
分子式 C26H22N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((2-(3-methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide

参考文献

1. Long Gu, et al. Cell Chem Biol. 2023 Jul 26;S2451-9456(23)00221-0.

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