ANT431 sodium |CAS 2292115-28-5 Probechem Biochemicals

Chemical Structure : ANT431 sodium

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ANT431 sodium (ANT 431, ANT-431)

货号: PC-63325Not For Human Use, Lab Use Only.

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

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生物&药学活性

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).
ANT431 potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.

物理化学性质&存储条件

分子量	308.282
分子式	C9H7N3NaO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid, sodium salt

参考文献

1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.

ANT431 sodium (ANT 431, ANT-431)

生物&药学活性

物理化学性质&存储条件

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ANT431 sodium (ANT 431, ANT-431)

生物&药学活性

物理化学性质&存储条件

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