ANI-7 | AhR agonist | Probechem Biochemicals

Chemical Structure : ANI-7

CAS No.: 931417-26-4

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ANI-7 (ANI 7;ANI7)

货号: PC-60774Not For Human Use, Lab Use Only.

ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway.
ANI-7 inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas).
ANI-7 potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage.
ANI-7 binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death.

物理化学性质&存储条件

分子量	263.121
分子式	C13H8Cl2N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile

参考文献

1. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.

ANI-7 (ANI 7;ANI7)

生物&药学活性

物理化学性质&存储条件

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ANI-7 (ANI 7;ANI7)

生物&药学活性

物理化学性质&存储条件

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