ANA-0 | Influenza PA inhibitor | Probechem Biochemicals

Chemical Structure : ANA-0

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ANA-0 (Influenza PA inhibitor)

货号: PC-49476Not For Human Use, Lab Use Only.

ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.
ANA-0 showed cross-subtype protection against influenza A virus infections in vitro and in vivo.
ANA-0 (20 uM) exhibited antiviral effects against infections of H3N2, H5N1, H7N7, H7N9 and H9N2 viruses in cell cultures.
ANA-0 showed IC50 of 2.5 uM against H5N1 and H7N7 viruses.
ANA-0 (2 mg/kg/day, intranasal treatment) inhibited virus growth in mice challenged with LD80 of mouse-adapted H1N1 virus, inhibited the viral transcription.
ANA-0 demonstrated synergistic antiviral effect when combined with zanamivir.

物理化学性质&存储条件

分子量	389.389
分子式	C19H11N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5Z)-2-[2-(2-oxoindol-3-yl)hydrazinyl]-5-(2-oxo-1H-indol-3-ylidene)-1,3-thiazol-4-one

参考文献

1. Shuofeng Yuan, et al. Sci Rep. 2016 Mar 9;6:22880.