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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-AN317
AN317

Chemical Structure : AN317

CAS No.: 946074-35-7

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AN317 (AN 317)

货号: PC-49027Not For Human Use, Lab Use Only.

AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM.
    AN317 displays functional selectivity toward other nAChRs, including α4β2, α3β4 and α7 receptors.
    AN317 induced [3H]dopamine release from rat striatal synaptosomes and augmented dopaminergic neuron activity in substantia nigra pars compacta brain slices in Ca2+ imaging and electrophysiological assays.
    AN317 alleviated the high-frequency tremors arising from reserpine-mediated dopamine depletion in rats.
    AN317 mediated significant protective effects on cultured rat mesencephalic neurons treated with the dopaminergic neurotoxin MPP+.
    AN317 displays good bioavailability and readily crosses the blood-brain barrier for in vivo research.

    物理化学性质&存储条件

    分子量 217.316
    分子式 C13H19N3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    9-methyl-3-(pyridin-3-yl)-3,9-diazabicyclo[3.3.1]nonane

    参考文献

    1. Sandager-Nielsen K, et al. Biochem Pharmacol. 2020 Apr;174:113786.

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