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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-AN2718
AN2718

Chemical Structure : AN2718

CAS No.: 174672-06-1

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AN2718 (AN-2718)

货号: PC-22624Not For Human Use, Lab Use Only.

AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.
AN2718 is an effective antimicrobial agent that can eradicate KPC-2 strains in vitro.
AN2718 can disrupt the homeostasis of energy metabolism by altering the NAD/NADH ratio and affecting ATP production, thereby blocking bacteria from growing.
AN2718 restores the antimicrobial activity of Meropenem in the treatment of carbapenem resistant infections in vivo.

物理化学性质&存储条件

分子量 168.38
分子式 C7H6BClO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

参考文献

1. Tang Y, et al. Int J Antimicrob Agents. 2024 Jul 5:107268.

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