AN12855 | InhA inhibitor | Probechem Biochemicals

Chemical Structure : AN12855

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AN12855 (AN-12855, AN 12855)

货号: PC-36156Not For Human Use, Lab Use Only.

AN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM, shows potent activity against whole-cell M. tuberculosis H37Rv with IC90 of 0.09 uM.

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生物&药学活性

AN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM, shows potent activity against whole-cell M. tuberculosis H37Rv with IC90 of 0.09 uM.
AN12855 demonstrates potent activity against drug-susceptible and drug-resistant strains of M. tuberculosis.
AN12855 exhibits comparable efficacy to the frontline antitubercular drug isoniazid (INH) in both acute and chronic models of TB infection with a lower potential for resistance development and shows in vitro activity against conventional KatG-mediated INH-resistant M. tuberculosis.

物理化学性质&存储条件

分子量	441.188
分子式	C17H15BF3N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-((2-(ethylsulfonyl)-1-hydroxy-1,2-dihydrobenzo[d][1,2,3]diazaborinin-7-yl)oxy)-5-(trifluoromethyl)benzaldehyde oxime

参考文献

1. Xia Y, et al. Life Sci Alliance. 2018 Jun 1;1(3):e201800025.

2. Robertson GT, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18.

AN12855 (AN-12855, AN 12855)

生物&药学活性

物理化学性质&存储条件

参考文献

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AN12855 (AN-12855, AN 12855)

生物&药学活性

物理化学性质&存储条件

参考文献

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