AN-329 | Hsp110 inhibitor | Probechem Biochemicals

Chemical Structure : AN-329

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AN-329 (AN-329/43448068)

货号: PC-23158Not For Human Use, Lab Use Only.

AN-329/43448068 (AN-329) is a small molecule inhibitor of Hsp110-STAT3 association, effectively inhibits HPAECs proliferation with IC50 of 22.67 uM, binds to bind to Hsp110 with KD of 12.6 uM.

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生物&药学活性

AN-329/43448068 (AN-329) is a small molecule inhibitor of Hsp110-STAT3 association, effectively inhibits HPAECs proliferation with IC50 of 22.67 uM, binds to bind to Hsp110 with KD of 12.6 uM.
AN-329/43448068 reduces the expression of p-STAT3 and c-Myc, inhibits hypoxia-induced proliferation and migration of HPAECs.
AN-329/43448068 effectively ameliorated hypoxia-induced PAH in rats.
AN-329/43448068 inhibited Hsp110-STAT3 signaling pathway in hypoxia-induced PAH rats.

物理化学性质&存储条件

分子量	445.58
分子式	C23H31N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(isopentyloxy)-N-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)benzamide

参考文献

1. Congke Zhao, et al. Eur J Med Chem. 2024 Sep 7:279:116855.

AN-329 (AN-329/43448068)

生物&药学活性

物理化学性质&存储条件

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AN-329 (AN-329/43448068)

生物&药学活性

物理化学性质&存储条件

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