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首页-小分子抑制剂&激动剂-Others-Other Targets-AMXT-1501
AMXT-1501

Chemical Structure : AMXT-1501

CAS No.: 441022-64-6

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AMXT-1501 (AMXT1501, AMXT 1501)

货号: PC-36047Not For Human Use, Lab Use Only.

AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO.
    AMXT-1501 completely blocked radiolabeled spermidine uptake in multiple NB cell lines, whereas the combination of AMXT 1501 and DFMO was synergistic in reducing colony formation in BE(2)-C and KELLY cells.
    The combination treatment resulted in hypophosphorylation of retinoblastoma protein (Rb), suggesting growth inhibition via G1 cell cycle arrest in NB cells.
    AMXT-1501 inhibits polyamine synthesis and uptake, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.

    物理化学性质&存储条件

    分子量 568.936
    分子式 C32H68N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide

    参考文献

    1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.

    2. Samal K, et al. Int J Cancer. 2013 Sep 15;133(6):1323-33.

    3. Hayes CS, et al. Cancer Immunol Res. 2014 Mar;2(3):274-85.

    4. Murray-Stewart TR, et al. Biochem J. 2016 Oct 1;473(19):2937-53.

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