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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-AMR-2
AMR-2

Chemical Structure : AMR-2

CAS No.: 877244-97-8

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AMR-2 (AMR2)

货号: PC-63567Not For Human Use, Lab Use Only.

AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.
    AMR-2 showed efficacy in the rat forced-swim and mouse tail suspension models with minimum effective doses of 0.3 and 1 mg/kg (po),.
    AMR-2 exhibits substantial occupancy levels at the three transporters in both rat and mouse brain.

    物理化学性质&存储条件

    分子量 364.507
    分子式 C22H24N2OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(4-(benzo[b]thiophen-5-yl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)morpholine

    参考文献

    1. Liu S, et al. ACS Med Chem Lett. 2014 May 13;5(7):760-5.

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