AMPKα1 activator 22f

Chemical Structure : AMPKα1 activator 22f

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货号: PC-25929Not For Human Use, Lab Use Only.

AMPKα1 activator 22f is a potent and selective AMPKα1 activator with EC50 of 35.1 nM (AMPKα1β1γ1), 176-fold selectivity over AMPKα2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

AMPKα1 activator 22f is a potent and selective AMPKα1 activator with EC50 of 35.1 nM (AMPKα1β1γ1), 176-fold selectivity over AMPKα2.
AMPKα1 activator 22f shows significant protective effect in NRK-52E cells subjected to hypoxia-reoxygenation injury.
AMPKα1 activator 22f selectively activates renal AMPKα1, significantly attenuating serum creatinine and blood urea nitrogen levels in RIRI mice model, alleviating kidney damage and reducing cellular infiltration.

物理化学性质&存储条件

分子量	453.95
分子式	C22H20ClN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5-((6-chloro-5-(4-(piperazin-1-yl)phenyl)-1H-indazol-3-yl)methylene)-3-methylthiazolidine-2,4-dione

参考文献

1. Hu Y, et al. Eur J Med Chem. 2025 Dec 30:305:118544.