AMPK activator SC4 |CAS:1364692-88-5 Probechem Biochemicals

Chemical Structure : AMPK activator SC4

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AMPK activator SC4

货号: PC-35495Not For Human Use, Lab Use Only.

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle.

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1 g		Get quote

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生物&药学活性

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle.
AMPK activator SC4 does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM.
Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

物理化学性质&存储条件

分子量	471.897
分子式	C26H18ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((6-Chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-3Himidazo[4,5-b]pyridin-2-yl)oxy)-2-methylbenzoic acid

参考文献

1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9.