Narmafotinib (AMP945, CTX-0294945) | FAK inhibitor | Probechem Biochemicals

Chemical Structure : AMP945

CAS No.: 1393653-34-3

加入收藏

AMP945 (Narmafotinib, CTX-0294945)

货号: PC-20058Not For Human Use, Lab Use Only.

Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.
AMP945 is highly selective for FAK across 468 kinase screening.
AMP945 shows potential for the treatment of pancreatic cancer in combination with standard of care gemcitabine and nab-paclitaxel.

物理化学性质&存储条件

分子量	527.59
分子式	C28H32F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[2-[[2-Methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]ethyl]benzeneacetamide

参考文献

1. John Lambert, et al. Cancer Res (2022) 82 (22_Supplement): A015.

AMP945 (Narmafotinib, CTX-0294945)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AMP945 (Narmafotinib, CTX-0294945)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.