AML874 | CDK8/CDK19 inhibitor | Probechem Biochemicals

Chemical Structure : AML874

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AML874 (AML-874)

货号: PC-28771Not For Human Use, Lab Use Only.

AML874 is a potent selective CDK8/CDK19 inhibitor with IC50 of 62 nM (CDK8), targets the Mediator complex and disrupts Mediator-dependent transcription, shows selective anti-leukemic activity.

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生物&药学活性

AML874 is a potent selective CDK8/CDK19 inhibitor with IC50 of 62 nM (CDK8), targets the Mediator complex and disrupts Mediator-dependent transcription, shows selective anti-leukemic activity.
AML874 exerts its anti-leukemic activity by inducing apoptosis rather than triggering cellular differentiation.
AML874 induces dose-dependent decrease in phospho-STAT1 levels in IFN-high KG-1 cells.
AML874 synergized with venetoclax in AML cell lines and patient-derived xenograft models, resulting in enhanced anti-leukemic activity in vivo.

物理化学性质&存储条件

分子量	321.38
分子式	C19H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(cyclopentylmethoxy)-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)methanone

参考文献

1. Aitchedji C, et al. Leukemia. 2026 Nov 11. doi: 10.1038/s41375-026-03173-0.

AML874 (AML-874)

生物&药学活性

物理化学性质&存储条件

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AML874 (AML-874)

生物&药学活性

物理化学性质&存储条件

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