AMG8379 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : AMG8379

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AMG8379 (AMG-8379)

货号: PC-60629Not For Human Use, Lab Use Only.

AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM.
AMG 8379 potently blocks endogenous tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglion (DRG) neurons with IC50 of 3.1 nM in whole-cell patch clamp electrophysiology assays.
AMG 8379 displays100- to 1000-fold selectivity over other NaV family members, including NaV1.4 and NaV1.5.
AMG 8379 blocks mechanically induced action potential firing in C-fibers, reduces the frequency of thermally induced C-fiber spiking.
AMG 8379 exhibits pharmacodynamic effects in translatable models of both itch and pain.

物理化学性质&存储条件

分子量	543.926
分子式	C25H16ClF2N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(P)-1-(3'-chloro-2,5'-difluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide

参考文献

1. Kornecook TJ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.

AMG8379 (AMG-8379)

生物&药学活性

物理化学性质&存储条件

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AMG8379 (AMG-8379)

生物&药学活性

物理化学性质&存储条件

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