AMG 837 |CAS:865231-46-5 Probechem Biochemicals

首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-AMG 837

Chemical Structure : AMG 837

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AMG 837 (AMG-837;AMG837)

货号: PC-43813Not For Human Use, Lab Use Only.

AMG 837 is a potent partial GPR40 (FFA1) agonist (EC50=13 nM for hGPR40).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AMG 837 is a potent partial GPR40 (FFA1) agonist (EC50=13 nM for hGPR40).
AMG 837 exhibits superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents; orally bioactive.

物理化学性质&存储条件

分子量	438.4384
分子式	C26H21F3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-,(βS)-

参考文献

1. Houze JB, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70.

2. Lin DC, et al. PLoS One. 2011;6(11):e27270.

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AMG 837 (AMG-837;AMG837)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMG 837 (AMG-837;AMG837)

生物&药学活性

物理化学性质&存储条件

参考文献

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